Scientific publications

For Whom the Cell Tolls? Intratumoral Treatment Links Innate and Adaptive Immunity

Feb 15, 2019 | Magazine: Clinical Cancer Research

Ivan Marquez-Rodas, María Angela Aznar, Antonio Calles, Ignacio Melero


Intratumoral immunotherapy can potentially modulate the tumor microenvironment (TME) and potentiate the effects of concomitant or sequential systemic immunotherapies. Intratumoral administration of different Toll-like receptor agonists, including TLR4, can potentiate these effects through innate and adaptive immunity connection.

CITATION  Clin Cancer Res. 2019 Feb 15;25(4):1127-1129. doi: 10.1158/1078-0432.CCR-18-2690. Epub 2018 Sep 27.