Scientific publications

The first 1000 days: an opportunity to reduce the burden of noncommunicable diseases

Mar 7, 2019 | Magazine: Nutrición Hospitalaria

Moreno Villares JM (1), Collado MC (2), Larqué E (3), Leis Trabazo R (4), Saenz De Pipaón M (5), Moreno Aznar LA (6)

(1) Clínica Universidad de Navarra.
(2) Instituto de Agroquímica y Tecnología de Alimentos. Consejo Superior de Investigaciones Científi cas (IATA-CSIC).
(3) Departamento de Fisiología. Universidad de Murcia. Instituto de Investigación Biosanitaria de Murcia (IMIB-Arrixaca).
(4) Unidad de Gastroenterología, Hepatología y Nutrición Pediátrica. Departamento de Pediatría. Hospital Clínico Universitario de Santiago. Universidad de Santiago de Compostela.
(5) Departamento de Neonatología. Hospital Universitario La Paz. Universidad Autónoma de Madrid.
(6) CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN). Instituto de Salud Carlos III.


Growth and development are determined by genetic and environmental factors since the very early embryonic life. Long-term health risks, as obesity and other non-communicable diseases (NCD), could be programmed since these early stages.

Early life, characterized by plasticity, is the ideal time to intervene and to prevent the risk of suffering a NCD (window of opportunity). Optimal nutrition during the first 1,000 days, since conception to the end of the second year of life, has a determinant role for long-term health.

Pregnancy, infancy and toddler periods have specific nutritional requirements. Intestinal microbiota enhances maturation and functioning of the immune system.

The interactions between host and intestinal microbiota are potential factors influencing early programming of the intestinal function. Alterations in intestinal colonization are associated to a higher risk of allergic diseases in childhood.

Scientific evidence supports the fact that the first 1,000 days are crucial to achieve a better long-term health and represents a strategic period to intervene under the perspective of prevention and public health.

CITATION  Nutr Hosp. 2019 Mar 7;36(1):218-232. doi: 10.20960/nh.02453