Factors related with post-surgical complications in elderly patients with glioblastoma multiforme
Martin-Risco M (1), Rodrigo-Paradells V (1), Olivera-Gonzalez S (2), Del Rio-Perez CM (1), Bances-Florez L (1), Calatayud-Perez JB (1), Villagrasa-Compaired FJ (1).
(1) Hospital Clinico Universitario Lozano Blesa, 50009 Zaragoza, Espana.
(2) Clinica del Hospital Clinico Lozano Blesa, Zaragoza, Espana.
Magazine: Revista de Neurología
Date: Feb 16, 2017Neurosurgery Department
Glioblastoma multiforme is the most frequent malignant tumour of the central nervous system, and its incidence reaches 80% in those over 50 years of age. Life expectancy has increased in the population in recent times and an analysis of the post-surgicalcomplications affecting elderly patients is of great importance for a correct surgical indication.
To analyse the factors related with post-surgical complications in elderly patients.
PATIENTS AND METHODS:
A sample of 88 patients diagnosed with glioblastoma multiforme between 31 and 78 years of age was analysed retrospectively. The variables taken into consideration in the study were: personal medical history, age, functional status, pre-anaesthetic status, tumour characteristics, type of surgery and post-surgical complications.
Age was observed to have an influence on local (p = 0.006) and systemic surgical complications (p = 0.034), and on the Clavien-Dindo scale (p = 0.001). Persons with a poorer functional status and cardiovascular risk presented more systemic complications (p = 0.006 and 0.044) and a lower score on the Clavien-Dindo scale (p = 0.024 and 0.025) respectively.
Likewise, more local complications are found in the case of excisional procedures than in biopsies (p = 0.027). The pre-anaesthetic status and anti-haemostatic treatments were not relatedwith such events.
Patients over 65 years of age present a higher incidence of pathological antecedents and a poorer pre-surgical functional status. Age, cardiovascular risk, functional status and the type of surgical procedure have significantly increased the occurrence of post-surgical complications.
CITATION Rev Neurol. 2017 Feb 16;64(4):162-168.
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