Scientific publications

European Association of Nuclear Medicine (EANM) Focus 4 consensus recommendations: molecular imaging and therapy in haematological tumours

May 8, 2023 | Magazine: Lancet Haematology

Cristina Nanni  1 , Carsten Kobe  2 , Bettina Baeßler  3 , Christian Baues  4 , Ronald Boellaard  5 , Peter Borchmann  6 , Andreas Buck  7 , Irène Buvat  8 , Björn Chapuy  9 , Bruce D Cheson  10 , Robert Chrzan  11 , Ann-Segolene Cottereau  12 , Ulrich Dührsen  13 , Live Eikenes  14 , Martin Hutchings  15 , Wojciech Jurczak  16 , Françoise Kraeber-Bodéré  17 , Egesta Lopci  18 , Stefano Luminari  19 , Steven MacLennan  20 , N George Mikhaeel  21 , Marcel Nijland  22 , Paula Rodríguez-Otero  23 , Giorgio Treglia  24 , Nadia Withofs  25 , Elena Zamagni  26 , Pier Luigi Zinzani  26 , Josée M Zijlstra  27 , Ken Herrmann  28 , Jolanta Kunikowska  29


Given the paucity of high-certainty evidence, and differences in opinion on the use of nuclear medicine for hematological malignancies, we embarked on a consensus process involving key experts in this area.

We aimed to assess consensus within a panel of experts on issues related to patient eligibility, imaging techniques, staging and response assessment, follow-up, and treatment decision-making, and to provide interim guidance by our expert consensus.

We used a three-stage consensus process. First, we systematically reviewed and appraised the quality of existing evidence. Second, we generated a list of 153 statements based on the literature review to be agreed or disagreed with, with an additional statement added after the first round.

Third, the 154 statements were scored by a panel of 26 experts purposively sampled from authors of published research on haematological tumours on a 1 (strongly disagree) to 9 (strongly agree) Likert scale in a two-round electronic Delphi review. The RAND and University of California Los Angeles appropriateness method was used for analysis. Between one and 14 systematic reviews were identified on each topic. All were rated as low to moderate quality. After two rounds of voting, there was consensus on 139 (90%) of 154 of the statements. There was consensus on most statements concerning the use of PET in non-Hodgkin and Hodgkin lymphoma. In multiple myeloma, more studies are required to define the optimal sequence for treatment assessment.

Furthermore, nuclear medicine physicians and haematologists are awaiting consistent literature to introduce volumetric parameters, artificial intelligence, machine learning, and radiomics into routine practice.

CITATION  Lancet Haematol. 2023 May;10(5):e367-e381. doi: 10.1016/S2352-3026(23)00030-3

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