Scientific publications

Epidermal growth factor receptor (EGFR) polymorphisms and survival in head and neck cancer patients

Eva Bandrés (a), Rubén Barricarte (a), Cristina Cantero (a), Beatriz Honorato (a), Raquel Malumbres (a), Ruth Zárate (a), Juan Alcalde (b), Jesús García-Foncillas (a)
(a) Laboratory of Pharmacogenomics, Cancer Research Program, Center for Applied Medical Research (CIMA), University of Navarra, Avda Pío XII 55, 31008-Pamplona, Spain.
(b) Department of Otolaryngology, Clínica Universitaria de Navarra, University of Navarra, Pamplona, Spain.

Magazine: Oral Oncology

Date: Aug 1, 2007

Otorhinolaryngology Department [SP] Medical Oncology Clinical Genetics Unit [SP]

EGFR overexpression has been implicated in the development of head and neck squamous cell carcinoma (HNSCC). This study evaluates the prognostic ability of four polymorphisms in EGFR gene for patients diagnosed with HNSCC and treated with chemoradiation.

EGFR polymorphisms in the promoter region were not associated with clinical or pathological characteristics. In relation to R497K polymorphism, patients with the Arg/Arg genotype showed the highest risk of disease-specificity mortality and none of the patients with the Lys/Lys genotype died throughout the follow-up period of the study. Patients with (CA)(n) repeats <17 in both alleles tended toward inferior overall survival compared with those with (CA)(n) repeats > or = 17 in both alleles (p=0.07). Moreover, the distribution of patients with any (CA)(n) repeats > or = 17 and both alleles <17 was statistically different across patients who were recorded as having partial response or no response to therapy (p=0.034).

Combination analysis of both polymorphisms, (CA)(n) repeats and R497K, suggests that these polymorphisms may be associated with clinical outcome in patients treated with chemoradiation.

CITATION  Oral Oncol. 2007 Aug;43(7):713-9



The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra


The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra


Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra