Early diagnosis of an allergic reaction to cisatracurium
The mortality of allergic reactions during anesthesia is estimated to be 6%, and between 1/10 000 and 1/1250 anesthetized patients die from such a reaction [1,2].
Given their quaternary ammonium structure, neuromuscular blocking agents (NMBAs) can behave as antigens. Consequently, they are responsible for more than two-thirds of anaphylactic or anaphylactoid reactions and for 80% of cases of anaphylactic shock during anesthesia .
The nondepolarizing muscle relaxant, cisatracurium, induces fewer allergic reactions than other NMBAs , such as succinylcholine, whose administration entails a higher risk than most of the other commonly used agents.
CITATION J Investig Allergol Clin Immunol. 2013;23(1):69-71