Dopaminergic system and neuronal death
Luquin M.R., Saldise L.
Departamento de Neurología y Neurocirugía, Clínica Universitaria de Navarra, Facultad de Medicina, Pamplona, España.
The mechanism involved in dopaminergic neuronal death remains unknown. Increased oxidative stress, inhibition of mitochondrial respiratory chain and apoptosis have been suggested as possible factors mediating cellular death. This article reviews the most important findings reported in parkinsonian brains related to nigral neuronal death.
CITATION Rev Neurol. 1997 Aug;25 Suppl 2:S129-40