Dopamine agonists suppress visual-cortical reflex myoclonus
Obeso JA, Artieda J, Tuñón T, Luquin MR, Martínez Lage JM.
From the Movement Disorders Unit, Department of Neurology, Clinica Universitaria, University of Navarra, Pamplona, Spain.
Magazine: Journal of Neurology, Neurosurgery and Psychiatry
Date: Dec 1, 1985Neurophysiology [SP] Neurology [SP]
Two patients with a diagnosis of olivo-ponto-cerebellar atrophy developed cortical reflex myoclonus to visual (flash) and somaesthetic stimuli.
Oral treatment with levodopacarbidopa (1000/100 mg) or subcutaneous administration of apomorphine (1 mg) abolished the visually-triggered myoclonus, without modifying reflex myoclonus to electrical or tactile stimulation. Intravenous administration of lisuride (0.1 mg) produced a marked reduction in both types of reflex myoclonus.
These results indicate a selective inhibitory effect of dopamine agonist drugs on visual reflex myoclonus of cortical origin.
CITATION J Neurol Neurosurg Psychiatry. 1985 Dec;48(12):1277-83
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