Scientific publications

Diagnostic Performance of Two-Dimensional Ultrasound, Two-Dimensional Sonohysterography and Three-Dimensional Ultrasound in the Diagnosis of Septate Uterus-A Systematic Review and Meta-Analysis

Feb 20, 2023 | Magazine: Diagnostics

Juan Luis Alcázar  1 , Isabel Carriles  1 , María Belén Cajas  2 , Susana Costa  3 , Sofia Fabra  4 , Maria Cabrero  2 , Elena Castro  5 , Aida Tomaizeh  6 , María Victoria Laza  7 , Alba Monroy  7 , Irene Martinez  6 , Maria Isabel Aguilar  6 , Elena Hernani  8 , Cristina Castellet  9 , Agustin Oliva  10 , María Ángela Pascual  9 , Stefano Guerriero  11   12

Background: The septate uterus is the most common congenital uterine anomaly, and hysteroscopy is the gold standard for diagnosing it. The goal of this meta-analysis is to perform a pooled analysis of the diagnostic performance of two-dimensional transvaginal ultrasonography, two-dimensional transvaginal sonohysterography, three-dimensional transvaginal ultrasound, and three-dimensional transvaginal sonohysterography for the diagnosis of the septate uterus.

Methods: Studies published between 1990 and 2022 were searched in PubMed, Scopus, and Web of Science. From 897 citations, we selected eighteen studies to include in this meta-analysis.

Results: The mean prevalence of uterine septum in this meta-analysis was 27.8%. Pooled sensitivity and specificity were 83% and 99% for two-dimensional transvaginal ultrasonography (ten studies), 94% and 100% for two-dimensional transvaginal sonohysterography (eight studies), and 98% and 100% for three-dimensional transvaginal ultrasound (seven articles), respectively. The diagnostic accuracy of three-dimensional transvaginal sonohysterography was only described in two studies, and we did not calculate the pooled sensitivity and specificity for this method.

Conclusion: Three-dimensional transvaginal ultrasound has the best performance capacity for the diagnosis of the septate uterus.

CITATION  Diagnostics (Basel). 2023 Feb 20;13(4):807.  doi: 10.3390/diagnostics13040807