Scientific publications

Current role of imaging techniques in cardiac amyloidosis

Dec 19, 2022 | Magazine: Medicina Clínica

Michal Pudis  1 , Gorka Bastarrika Alemañ  2


Cardiac amyloidosis (CA) is an underdiagnosed disease and, if left untreated, rapidly fatal. Emerging therapies for CA increase the urgency of developing non-invasive diagnostic methods for its early detection and for monitoring therapeutic response.

Classic imaging features on echocardiography and cardiac magnetic resonance, although typical for cardiac amyloidosis, are not specific enough to distinguish light chain amyloidosis from transthyretin. Myocardial bone-avid radiotracer uptake is highly specific for transthyretin cardiac amyloidosis when plasma cell dyscrasia has been excluded; it is now replacing the need for biopsy in many patients.

Detection of early cardiac amyloidosis, quantitation of its burden, and assessment of response to therapy are important next steps for imaging to advance the evaluation and management of cardiac amyloidosis.

CITATION  Med Clin (Barc). 2022 Dec 19;S0025-7753(22)00530-9. doi: 10.1016/j.medcli.2022.09.010

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