Scientific publications

COVID-19 in patients with hematological malignancies: Considering the role of tyrosine kinase inhibitors

Jun 1, 2021 | Magazine: Cancer

Alejandro Morales-Ortega  1 , Jaime García de Tena  2 , Begoña Frutos-Pérez  1 , Beatriz Jaenes-Barrios  3 , Ana Isabel Farfán-Sedano  1 , Miguel Ángel Canales-Albendea  4 , David Bernal-Bello  1

In an article previously published in Cancer, Cattaneo et al1 analyzed a cohort of patients with coronavirus disease 2019 (COVID-19) and hematological malignancies in March 2020, and they highlighted that subjects with chronic myeloid leukemia (CML) had a lower than expected frequency of COVID-19. The authors linked this observation to the lower level of immunodeficiency seen in CML and to a potential protective role of tyrosine kinase inhibitors (TKIs) based on the possible antiviral activity of these drugs. However, they reported a mortality rate 30 days after the documentation of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of 50% in the group of patients with chronic myeloproliferative malignancies, which included patients with CML (78% of these patients were treated with TKIs).

CITATION  Cancer. 2021 Jun 1;127(11):1937-1938.  doi: 10.1002/cncr.33432. Epub 2021 Mar 15.

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