Contraceptives and ischemic cardiopathy
García-Bolao I., Alegría E., Iglesias I., Velasco S., Alzamora P., Fidalgo M.L.
The incidence of myocardial infarction is higher in women that use oral contraceptives. The most important pathophysiologic mechanisms are:
- modification of coronary risk factors: the pill produces an elevation of both serum cholesterol and trygliceride levels, increase of blood pressure and decompensation of diabetes mellitus
- blood coagulation disorders: oral contraceptives increase platelet aggregation and fibrinogen blood levels, therefore they have a considerable thrombogenic capacity.
At this moment there are several update publications concerning this matter; however most of the mechanisms involved in the increase of coronary heart disease in this specific group still remain unclear.
CITATION Rev Med Univ Navarra. 1990 Jul-Sep;34(3):144-50