Concurrent clarithromycin and cyclosporin A treatment
Magazine: The Journal of Antimicrobial Chemotherapy
Date: Sep 1, 1998Hepatology Clinical Research Unit [SP] Clinical Pharmacology [SP]
Although macrolides have been associated with significant pharmacokinetic interactions, clarithromycin is considered to have a low interaction capacity. In this study, six transplant recipients treated with cyclosporin A also received clarithromycin. In all patients, the dose of cyclosporin A had to be reduced by a mean of 33% per day depending on the macrolide dose.
Normalization of the dosage parameters began on the fourth day after stopping clarithromycin treatment. Co-administration of cyclosporin A and clarithromycin may lead to increases in whole blood cyclosporin levels, and appropriate dose reductions should be considered.
CITATION J Antimicrob Chemother. 1998 Sep;42(3):393-5
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