Scientific publications

Concurrent clarithromycin and cyclosporin A treatment

Sep 1, 1998 | Magazine: The Journal of Antimicrobial Chemotherapy

Sádaba B, López de Ocáriz A, Azanza JR, Quiroga J, Cienfuegos JA.
Clinical Pharmacology Department, University Clinic of Navarra School of Medicine, Pamplona, Spain.


Although macrolides have been associated with significant pharmacokinetic interactions, clarithromycin is considered to have a low interaction capacity. In this study, six transplant recipients treated with cyclosporin A also received clarithromycin. In all patients, the dose of cyclosporin A had to be reduced by a mean of 33% per day depending on the macrolide dose.

Normalization of the dosage parameters began on the fourth day after stopping clarithromycin treatment. Co-administration of cyclosporin A and clarithromycin may lead to increases in whole blood cyclosporin levels, and appropriate dose reductions should be considered.

CITATION  J Antimicrob Chemother. 1998 Sep;42(3):393-5

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