Scientific publications

Comparative effects of gastric bypass and sleeve gastrectomy on plasma osteopontin concentrations in humans

Lancha A (1), Moncada R, Valentí V, Rodríguez A, Catalán V, Becerril S, Ramírez B, Méndez-Giménez L, Gil MJ, Rotellar F, Fernández S, Salvador J, Frühbeck G, Gómez-Ambrosi J.
(1) Metabolic Research Laboratory, Clínica Universidad de Navarra, Irunlarrea 1, 31008, Pamplona, Spain. 

Magazine: Surgical Endoscopy

Date: Aug 1, 2014

General and Digestive Surgery Endocrinology and Nutrition [SP] Obesity Unit Biochemistry [SP]


Bariatric surgery (BS) has proven to be an effective treatment for morbid obesity. Osteopontin (OPN) is a proinflammatory cytokine involved in the development of obesity. The aim of our study was to determine the effect of weight loss following BS on circulating levels of OPN in humans.


Body composition and circulating concentrations of OPN and markers of bone metabolism were determined in obese patients who underwent Roux-en-Y gastric bypass (RYGB; n = 40) or sleeve gastrectomy (SG; n = 11).


Patients who underwent RYGB or SG showed decreased body weight (P < 0.001) and body fat percentage (P < 0.001) as well as lower insulin resistance. However, plasma OPN levels were significantly increased after RYGB (P < 0.001) but remained unchanged following SG (P = 0.152). Patients who underwent RYGB also showed significantly increased C-terminal telopeptide of type-I collagen (ICTP) (P < 0.01) and osteocalcin (P < 0.001) while bone mineral density tended to decrease (P = 0.086).

Moreover, OPN concentrations were positively correlated with the bone resorption marker ICTP after surgery. On the other hand, patients who underwent SG showed significantly increased ICTP levels (P < 0.05), and the change in OPN was positively correlated with the change in ICTP and negatively with the change in vitamin D after surgery (P < 0.05).


RYGB increased circulating OPN levels, while they remained unaltered after SG. The increase in OPN levels after RYGB could be related to the increased bone resorption in relation to its well-known effects on bone of this malabsorptive procedure in comparison to the merely restrictive SG.

CITATION  Surg Endosc. 2014 Aug;28(8):2412-20. doi: 10.1007/s00464-014-3490-1. Epub 2014 Mar 13.



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