Scientific publications

Chronic migraine: a therapeutic challenge for clinicians

Sep 21, 2012 | Magazine: Expert Opinion on Emergeging Drugs

Irimia P, Carmona-Abellán M, Martínez-Vila E.
Department of Neurology, Clinica Universidad de Navarra , Avenida Pío XII, 36, 31008-Pamplona , Spain

Chronic migraine is a common disabling condition. Severe migraine attacks should be treated with triptans, but these agents are contraindicated in patients with vascular problems and may not be effective or tolerated in around one third of the patients. New acute migraine therapies without vasoconstrictive activity and triptan-specific side effects are emerging. For the prophylaxis of chronic migraine, only topiramate and Onabotulinumtoxin.

A have been shown to be effective in placebo-controlled randomized trials, so novel therapeutic strategies are needed. The growing understanding of the pathophysiology of chronic migraine will contribute to the identification of new treatment targets.


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