Scientific publications

Cervical prolapse during pregnancy and Klippel-Trenaunay syndrome

Jul 1, 2009 | Magazine: International Journal of Gynecology and Obstetrics

Minguez JA, Aubá M, Olartecoechea B.
Department of Obstetrics and Gynecology, University Clinic and School of Medicine, University of Navarra, Pamplona, Spain

Although it is rare in pregnancy (1 case per 10 000–15 000 pregnancies), prolapse of the uterine cervix occurs more frequently in white multiparous women. Klippel–Trenaunay syndrome is a rare hereditary disease with a characteristic diagnostic triad of capillary–venous malformations (98% of cases), venous varicosities (70%–80% of cases), and underlying soft-tissue or bone hypertrophy (50%–94% of cases) commonly affecting the lower extremities.

The presence of 2 of these features is sufficient for diagnosis of the condition. Klippel–Trenaunay syndrome is benign yet progressive, and can worsen with the physiologic changes that occur during pregnancy—such as increased blood volume, and venous stasis and edema in the lower extremities.

Other complications include massive bleeding due to entrapped platelets, thrombophlebitis, heart failure from arteriovenous fistulas, intravascular coagulation, and preterm deliver.

CITATION  Int J Gynaecol Obstet. 2009 Nov;107(2):158