Scientific publications

Asthenia in advanced cancer and the use of psychostimulants

Oct 1, 2011 | Magazine: Anales del Sistema Sanitario de Navarra

Portela M, Sanz A, Martínez M, Centeno C.
Unidad de Medicina Paliativa y Control de Síntomas, Clínica Universidad de Navarra, Pamplona, 31008


Asthenia is the most frequent symptom in patients with advanced cancer and is probably what most affects the quality of life of oncology patients since it interferes in their physical and social activity. Treatment in the majority of cases is symptomatic.

There is growing interest in the use of psychostimulants for treating asthenia. Methylphenidate and modafinil are two psychostimulants that have already been tested in controlled studies on asthenia of the patient with advanced cancer; they have proved to be efficient, particularly in patients in very advanced stages who are very tired.

CITATION  An Sist Sanit Navar. 2011 septiembre-diciembre;34(3):471-479