Association between 18F fluorodeoxyglucose uptake and prognostic parameters in breast cancer
A. Gil-Rendo (1), F.Martínez-Regueira (1), G. Zornoza (1), M. J. García-Velloso (2), C. Beorlegui (1) and N. Rodriguez-Spiteri (1)
Departments of (1)Surgery and (2)Nuclear Medicine, Clinica Universitaria of Navarra, C/Pío XII 36, 31008 Pamplona, Navarra, Spain
This study analysed the correlation between [(18)F]fluorodeoxyglucose (FDG) uptake assessed by positron emission tomography (PET) in breast tumours, and histopathological and inmunohistochemical prognostic factors.
FDG-PET was performed before surgery in 275 women with primary breast cancer. The standarized uptake value (SUV) was compared with histopathological findings after surgery.
A positive relationship was found between the SUV and tumour size (r = 0.46, P < 0.001), axillary lymph node status (P < 0.001), histological type (P < 0.001), histological grade (P < 0.001), oestrogen receptor status (P < 0.001), p53 (P < 0.001) and Ki-67 (P < 0.001) expression. Multivariable linear regression showed that tumour size, histological grade, Ki-67 expression, oestrogen receptor status and histological type were significantly related to the SUV.
The SUV is a preoperative and non-invasive metabolic factor that relates to some prognostic factors in breast cancer.
CITATION Br J Surg. 2009 Feb;96(2):166-70