Allergic rhinitis causes loss of smell in children: The OLFAPEDRIAL study
Langdon C (1,2), Guilemany JM (1,2), Valls M (1), Alobid I (1,2), Bartra J (3,4), Dávila I (5), Del Cuvillo A (6), Ferrer M (7,4), Jáuregui I (8), Montoro J (9), Sastre J (10), Valero A (3,2), Mullol J (11,12).
The objective of the OLFAPEDRIAL study was to assess the olfactory dysfunction in allergic paediatric population, which has been scarcely studied.
Observational, cross-sectional, and multicentre study evaluated the sense of smell in untreated allergic rhinitis (AR) paediatric patients aged 6-12 yrs.
Fourty-four percent (551 out of 1260) of children with AR reported smell dysfunction, with both loss of smell frequency (52.1%, p<0.001) and intensity (0.75±0.84, p<0.0001) being more frequent in patients with persistent than intermittent AR (38.0% and 0.51±0.73, respectively).
In addition, both loss of smell frequency and intensity increased according to disease severity (m-ARIA classification) but always being significantly higher in persistent (p<0.0001) than in intermittent AR.
Children with allergic rhinitis present a mild-moderate loss of smell which frequency and intensity is clearly related to the disease duration and severity. The loss of smell can be considered, as in adults, a clinical marker of disease severity.
CITATION Pediatr Allergy Immunol. 2016 Sep 9. doi: 10.1111/pai.12655