Adjuvants for allergy immunotherapeutics
Gamazo C (1), D Amelio C (2), Gastaminza G (3), Ferrer M (4), Irache JM (5).
(1a) Dept. Microbiology, Instituto de Investigación Sanitaria de Navarra (Idisna), University of Navarra - C/Irunlarrea, 1; 31080 - Pamplona, Spain
(2b) Department of Allergology and Clinical Immunology, Clínica Universidad de Navarra - address: Av. Pio XII 36, 31008-Pamplona-Spain.
(3c) Department of Allergology and Clinical Immunology, Clínica Universidad de Navarra - address: Av. Pio XII 36, 31008-Pamplona-Spain.
(4d) Department of Allergology and Clinical Immunology, Clínica Universidad de Navarra - address: Av. Pio XII 36, 31008-Pamplona-Spain.
(5e) University of Navarra , Dept. Pharmacy and Pharmaceutical Technology; C/Irunlarrea, 1; 31080 - Pamplona, Spain.
Magazine: Human Vaccines & Immunotherapeutics
Date: Aug 21, 2017Allergology and Immunology Department
Allergic diseases are reaching epidemic proportions in developed countries. In particular, food allergy is increasing in prevalence and severity, thus becoming an important socioeconomic burden. Numerous cell types and cell populations, which form an intricate and balanced network, are involved in an immune response.
This balance is occasionally disturbed, leading to the onset of different diseases, such as allergic diseases. Antihistamines and corticosteroids provide some degree of relief from the symptoms of allergic conditions. However, the only treatment that can revert the disease is immunotherapy. Nevertheless, specific immunotherapy has at least two major drawbacks: it is time-consuming, and it can produce local and even systemic allergic side effects. Immunotherapy's potential goes beyond our current knowledge of the immune response; nevertheless, we can still design strategies to reach a safer immune modulation for treating allergies.
This review deals with the use of adjuvants to reduce the undesirable side effects associated with specific allergen immunotherapy. For example, nanoparticles used as immunoadjuvants are offering promising results in preclinical assays.
CITATION Hum Vaccin Immunother. 2017 Aug 21:0. doi: 10.1080/21645515.2017.1348447
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