Adipokines in the treatment of diabetes mellitus and obesity
Victoria Catalán (1,3), Javier Gómez-Ambrosi (1,3), Amaia Rodríguez (1,3), Javier Salvador (2,3) & Gema Frühbeck (1,2,3)
(1) Clínica Universitaria de Navarra, Metabolic Research Laboratory, University of Navarra, Pamplona, Spain
(2) Department of Endocrinology, Clínica Universitaria de Navarra, Pamplona, Spain
(3) CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain
The physiology of adipose tissue plays a main role in the pathogenesis of type 2 diabetes mellitus. The secretion of adipocyte-derived hormones, in either an autocrine or a paracrine manner, has been proposed as a relevant mechanism in this process. In this sense, the administration and regulation of hormones derived from adipose tissue arises as an attractive option for treating metabolic disorders.
To review the current understanding of the implication of adipokines in the development of obesity and insulin resistance, as well as their potential use as therapeutic agents.
Review of scientific literature.
This review describes the role of adipokines in generating insulin resistance and the chronic low-grade inflammatory profile accompanying visceral obesity.
CITATION Expert Opin Pharmacother. 2009 Feb;10(2):239-54