Acute generalized exanthematous pustulosis induced by sorafenib
Pretel M1, Iñarrairaegui M 1, Lera JM1, Idoate MA2
1Department of Dermatology, School of Medicina, University Clinic of Navarra, Pamplona, Spain
2Department of Pathology, School of Medicina, University Clinic of Navarra, Pamplona, Spain
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Sorafenib (Nexavar; Bayer HealthCare AG) is an oral multikinase inhibitor approved by the US Food and Drug Administration for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma. It inhibits multiple tyrosine kinases, including C-RAF and B-RAF, vascular endothelial growth factor receptors, and platelet-derived growth factor receptor (PDGFR).
Acute generalized exanthematous pustulosis (AGEP) is a rare skin eruption associated principally with drugs. To our knowledge, only 1 report of sorafenib-induced acute localized exanthematous pustulosis (ALEP) has been published. Herein, we report the first case of AGEP induced by sorafenib.
CITATION JAMA Dermatol. 2014 Jun 1;150(6):664-6. doi: 10.1001/jamadermatol.2013.6924.