Acute generalized exanthematous pustulosis induced by sorafenib
Pretel M1, Iñarrairaegui M 1, Lera JM1, Idoate MA2 1Department of Dermatology, School of Medicina, University Clinic of Navarra, Pamplona, Spain
2Department of Pathology, School of Medicina, University Clinic of Navarra, Pamplona, Spain
Magazine: JAMA Dermatology
Date: Jun 1, 2014Hepatology Pathological Anatomy [SP] Dermatology
Sorafenib (Nexavar; Bayer HealthCare AG) is an oral multikinase inhibitor approved by the US Food and Drug Administration for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma. It inhibits multiple tyrosine kinases, including C-RAF and B-RAF, vascular endothelial growth factor receptors, and platelet-derived growth factor receptor (PDGFR).
Acute generalized exanthematous pustulosis (AGEP) is a rare skin eruption associated principally with drugs. To our knowledge, only 1 report of sorafenib-induced acute localized exanthematous pustulosis (ALEP) has been published. Herein, we report the first case of AGEP induced by sorafenib.
CITATION JAMA Dermatol. 2014 Jun 1;150(6):664-6. doi: 10.1001/jamadermatol.2013.6924.
you mayBE INTERESTED
The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.
The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.
Learn why we are different from other healthcare centers. Quality, speed, comfort and results.