A long-term retrospective review of 5 cases using daptomycin for prosthetic device infections after surgery
Quetglas EG, San Julian M, Garcia Tutor E, Vazquez B, Lucena F, Landecho M, Azanza JR.
To review the antimicrobial possibilities for limb-sparing due to infectious complications after surgery in patients diagnosed with osteosarcoma and with implantation of prosthetic devices.
Patients and Progress
After several episodes of relapsing infection or even re-infection and failure of previous therapies, 5 patients (2 young, female / 1 young, male / 2 middle-aged, female) were subject to a long-term ambulatory regimen consisting of intravenous administration of daptomycin.
Showed improved outcome with preservation of the limbs or devices involved. Conclusion: Five patients with post-operative gram-positive suspected infections of prosthetic devices that were unresponsive to a variety of other antibiotics and combinations appeared to respond to compassionate use of daptomycin. its effectiveness is probably due to its activity against biofilmproducing microorganisms. Controlled, double-blind randomized trials are needed to confirm the potential of daptomycin in such patients.
CITATION Int J Artif Organs. 2009 May;32(5):299-307