5'-Upstream variants of CRHR1 and MAPT genes associated with age at onset in progressive supranuclear palsy and cortical basal degeneration
Carlos Cruchaga (a), Jose M. Vidal-Taboada (a), Mario Ezquerra (b), Elena Lorenzo (a), Pablo Martinez-Lage (c), Marta Blazquez (d), Eduardo Tolosa (b), The Iberian Atypical Parkinsonism Study Group Researchers 1 and Pau Pastor (a, e)
(a) Neurogenetics Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
(b) Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Department of Medicine, Universitat de Barcelona, IDIBAPS, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain
(c) Fundacio ACE, Barcelona, Spain
(d) Neurology Department, Hospital Universitario Central de Asturias, Oviedo, Spain
(e) Department of Neurology, Clínica Universitaria de Navarra, University of Navarra, Pamplona, Spain
Two different H1 sub-haplotypes at chromosome 17q21, H1C and H1E'A, have been associated with progressive supranuclear palsy (PSP) and cortical basal degeneration (CBD).
We analyzed the SNPs included in the H1C and H1E'A haplotypes in a large Spanish PSP/CBD series and their interaction with age at onset (AAO). Survival analysis of rs1880753 marker was consistently associated with disease risk and with an earlier age at onset under an additive model.
Its location at 160 kb and 50 kb upstream of tau and CRHR1 genes, respectively, suggests that it might act as a cis-element that regulates gene expression. Rs45502095(H1) was also associated with AAO under a recessive model. Haplotype analysis failed to replicate the association of H1C and H1E'A haplotypes with PSP/CBD. However, we found a strong association of two H1 sub-haplotypes with PSP and CBD (H1E'C and H1Q), which include MAPT and CRHR1 genes where the risk variant for PSP/CBD could lie.
CITATION Neurobiol Dis. 2009 Feb;33(2):164-70