Scientific publications

4-1BB (CD137) in anticancer chimeras

Dec 7, 2020 | Magazine: The Journal of Experimental Medicine

Ignacio Melero, Pedro Berraondo


4-1BB (CD137, TNFRSF9) mediates costimulatory signals important for activation and persistence of cytotoxic T lymphocytes. In this issue of JEM, Oda et al. ( report on a chimeric construction encompassing extracellular Fas and intracellular 4-1BB to dramatically improve adoptive T cell therapy.

CITATION J Exp Med. 2020 Dec 7;217(12):e20201562.  doi: 10.1084/jem.20201562