37th Annual San Antonio Breast Cancer Symposium. Resumen de las aportaciones translacionales y clínicas más relevantes

ABSTRACT

The 37th San Antonio Breast Cancer Symposium, held in December 2014, provided an opportunity to gain greater knowledge.

Notable contributions were the following:

1. in basic research, the acquisition of mutations in carcinogenesis and metastasis, which increase with clonality and heterogeneity; the prognostic role of neoantigens and infiltrating lymphocytes in the residual tumor after neoadjuvant chemotherapy; and an increased knowledge of molecular mutations in the estrogen receptor, which explain hormonal resistance
2. in the translational arena, the role of patient-derived xenografts to avoid therapeutic resistance; and the role of liquid biomarkers to detect minimal residual disease in early breast cancer
3. in the clinical scenario, advances in prevention and hormone therapy, and news on triple-negative tumors and immunotherapy.

CITATION  Revista de Senología y Patología Mamaria 03/2015; DOI: 10.1016/j.senol.2015.02.001