37th Annual San Antonio Breast Cancer Symposium. Resumen de las aportaciones translacionales y clínicas más relevantes
M. Santisteban, S. de la Cruz, J. Espinós, J.M. Aramendía, O. Fernández Hidalgo
The 37th San Antonio Breast Cancer Symposium, held in December 2014, provided an opportunity to gain greater knowledge.
Notable contributions were the following:
- in basic research, the acquisition of mutations in carcinogenesis and metastasis, which increase with clonality and heterogeneity; the prognostic role of neoantigens and infiltrating lymphocytes in the residual tumor after neoadjuvant chemotherapy; and an increased knowledge of molecular mutations in the estrogen receptor, which explain hormonal resistance
- in the translational arena, the role of patient-derived xenografts to avoid therapeutic resistance; and the role of liquid biomarkers to detect minimal residual disease in early breast cancer
- in the clinical scenario, advances in prevention and hormone therapy, and news on triple-negative tumors and immunotherapy.
CITATION Revista de Senología y Patología Mamaria 03/2015; DOI: 10.1016/j.senol.2015.02.001