Scientific publications

120 hours simultaneous infusion of cisplatin and fluorouracil in metastatic breast cancer

Sep 30, 1989 | Magazine: American Journal of Clinical Oncology

Fernández Hidalgo O., González F., Gil A., Campbell W., Barrajón E., Lacave A.J.

Thirty-six patients with metastatic breast cancer, 23 with documented progression of the disease after first-line chemotherapy (CAF or CMF) and 13 without prior chemotherapy, were treated with a simultaneous 120-h infusion of cisplatin (CDDP) and 5-fluorouracil (5-FU).

Objective response was demonstrated in 19 patients (52.7%), stable disease in 7 patients (19.4%) and progression of the disease in 10 patients (27.7%). Similar response rate was observed according to tumor site (soft tissues, 50%; bone, 52%; lung, 63%; liver, 55%; and pleura and peritoneum, 42%) and previous treatment (previous chemotherapy, 48%; previously untreated, 61%).

Median duration of response was 8 months. Toxicity was characterized by stomatitis and myelodepression and required dose adjustments in 30% of patients. CDDP and 5-FU infusion deserve further investigation because it appeared to have substantial activity in this preliminary study in metastatic breast cancer.

CITATION  Am J Clin Oncol. 1989 Oct;12(5):397-401.  doi: 10.1097/00000421-198910000-00007.