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We are the only private hospital in Spain that performs transplantations of haematopoietic stem cells from donors (allogeneic).
EXPERIENCE
We perform between 20 and 30 bone marrow transplantations per year using both the patient's own cells (autologous) and those of donors (allogeneic).
TEAMWORK
Our team of professionals will be in direct contact with the specialists of your referring clinic.
SPEED, ACCESS, AND PRECISION
We issue a response within 48 hours about the suitability of the treatment for each patient.
AUTOTRANSPLANTATION (AUTOLOGOUS):
The patient's own progenitor cells are extracted and stored in order for them to subsequently be re-infused into the patient.
WITH A DONOR (ALLOGENEIC):
Syngeneic transplantation: this type of transplantation is performed between identical twins and is not associated with immunological events.
Allogeneic transplantation: this type of transplantation is performed between two individuals with genetic differences, but with the greatest possible similarities in their leukocyte antigens.
AUTOTRANSPLANTATION (AUTOLOGOUS):
The patient's own progenitor cells are extracted and stored in order for them to subsequently be re-infused into the patient.
WITH A DONOR (ALLOGENEIC):
Syngeneic transplantation: this type of transplantation is performed between identical twins and is not associated with immunological events.
Allogeneic transplantation: this type of transplantation is performed between two individuals with genetic differences, but with the greatest possible similarities in their leukocyte antigens.
AUTOTRANSPLANTATION (AUTOLOGOUS):
The patient's own progenitor cells are extracted and stored in order for them to subsequently be re-infused into the patient.
WITH A DONOR (ALLOGENEIC):
Syngeneic transplantation: this type of transplantation is performed between identical twins and is not associated with immunological events.
Allogeneic transplantation: this type of transplantation is performed between two individuals with genetic differences, but with the greatest possible similarities in their leukocyte antigens.
AUTOTRANSPLANTATION (AUTOLOGOUS):
The patient's own progenitor cells are extracted and stored in order for them to subsequently be re-infused into the patient.
WITH A DONOR (ALLOGENEIC):
Syngeneic transplantation: this type of transplantation is performed between identical twins and is not associated with immunological events.
Allogeneic transplantation: this type of transplantation is performed between two individuals with genetic differences, but with the greatest possible similarities in their leukocyte antigens.
In general, haematopoietic stem cell transplantations are indicated in patients with haematological cancers or altered bone marrow functions:
- Multiple myeloma
- Leukaemia
- Certain lymphomas
- Other serious blood diseases, such as thalassemia, aplastic anaemia, and sickle cell anaemia
- Certain diseases of the immune system
- Multiple sclerosis
In general, haematopoietic stem cell transplantations are indicated in patients with haematological cancers or altered bone marrow functions:
- Multiple myeloma
- Leukaemia
- Certain lymphomas
- Other serious blood diseases, such as thalassemia, aplastic anaemia, and sickle cell anaemia
- Certain diseases of the immune system
- Multiple sclerosis
A bone marrow transplantation is a procedure in which a normal bone marrow function is restored and defective stem cells are replaced. When transplanted, these cells repopulate the bone marrow and resume the normal production of healthy blood cells and platelets.
Before undergoing a transplantation, patients receive a "conditioning" treatment consisting of high doses of chemotherapy and, occasionally, radiotherapy, in order to eliminate damaged stem cells present in the bone marrow.
This depresses the patient's immune system so that it does not attack the new stem cells that the patient will receive by means of the transplantation.
AUTOTRANSPLANTATION (AUTOLOGOUS):
The patient's own progenitor cells are extracted and stored in order for them to subsequently be re-infused into the patient.
WITH A DONOR (ALLOGENEIC):
Syngeneic transplantation: this type of transplantation is performed between identical twins and is not associated with immunological events.
Allogeneic transplantation: this type of transplantation is performed between two individuals with genetic differences, but with the greatest possible similarities in their leukocyte antigens.
TRANSPLANTATION: AN OPTION FOR PATIENTS WITH MULTIPLE SCLEROSIS
Multiple sclerosis is a disease that affects the brain and the spinal cord. Due to its autoimmune origin, the transplantation of the patient's own haematopoietic stem cells has become one of the most effective therapeutic alternatives available to date.
This effectiveness has been demonstrated in recent clinical trials whose conclusions revealed that the autologous transplantation of bone marrow progenitor cells yields better results than conventional treatment in patients with relapsing-remitting multiple sclerosis, in which case seizures or relapses are followed by periods of remission.
Recent research has corroborated the efficacy of transplantations in slowing disease progression and improving the patient’s symptoms. The aim of the therapy is for the new stem cells to be able to rebuild the patient's bone marrow and immune system.
PRE-TRANSPLANTATION CONSULTATION
The patient will undergo a first clinical evaluation carried out by our team of specialists.
EVALUATION
In order to assess whether the patient is a suitable candidate for this treatment, complete blood tests, an echocardiogram, respiratory function tests, and a chest x-ray are performed.
PRE-TRANSPLANTATION TREATMENT
Before receiving the transplant, the patient will be treated with growth factors and/or chemotherapy.
PROTOCOL ASSIGNMENT
If the patient is eligible for the treatment, s/he will be assigned to one of the two possible treatment protocols: transplantation of stem cells from the patient (autologous) or from a donor (allogeneic).
AUTOLOGOUS TRANSPLANT
The stem cells are extracted in the Apheresis Unit and processed in the Laboratory of the Cell Therapy Area.
DONOR TRANSPLANT
The donor will be tested to confirm that there is no contraindication, and will have the cells extracted in the Apheresis Unit and processed in the Laboratory of the Cell Therapy Area.
HOSPITALIZATION
The patient will be admitted to the Clinic’s Transplantation Unit for 2 to 4 weeks.
CONDITIONING THERAPY
The patient will receive chemotherapy and/or radiotherapy in order to prepare their body to receive the transplant.
CELL INFUSION
The progenitor cells are administered by means of a transfusion lasting 30 minutes to 1 hour.
The transplantation procedure performed at the Clinic
The main goal of our Clinic is to offer the best medical and human treatment to its patients and their family members, which is why the entire organization was designed for this purpose.
- Our physicians will always be available for the patients, and this availability translates into extremely agile and convenient patient care.
- You may receive medical attention from professionals specializing in different fields on the same morning, thus receiving a multidisciplinary treatment in a very tight timeframe.
SPECIALISTS
A HIGHLY SPECIALIZED TEAM
The Haematology and Haemotherapy Service of our Clinic is comprised by a team of highly specialized professionals with extensive experience in bone marrow transplantations.
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Dr. Ana Alfonso Piérola
Specialist of the Haematology and Haemotherapy Service
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Dr. Enrique Andreu Oltra
Specialist of the Cell Therapy Area
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Goreti Ariz Eransus
Nurse of the Cell Therapy Area
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Carmen Azcona Urra
Nurse of the Haematology and Haemotherapy Service
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Dr. José Rifón Roca
Specialist of the Haematology and Haemotherapy Service
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Dr. Paula Rodríguez Otero
Specialist of the Haematology and Haemotherapy Service
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Dr. Sara Villar Fernández
Specialist of the Haematology and Haemotherapy Service
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Ana Zafra Molina
Head Nurse of the Haematology and Haemotherapy Service
BONE MARROW TRANSPLANTATION: THE VALUE OF OUR RESEARCH
In addition to boasting solid experience in this procedure, the healthcare professionals working at the Clinic's Haematopoietic Transplantation Unit have published several scientific articles on this matter in high-impact journals of their specialty, such as the European Journal of Haematology or the British Journal of Haematology, among the most recent ones.
Various clinical trials are currently underway in the Haematopoietic Transplantation Unit:
Pre-transplantation conditioning with radioimmunotherapy involving both the transplantation of the patient’s own cells (autologous) and that of donor cells (allogeneic).
Treatment of graft-versus-host disease using mesenchymal bone marrow stem cells produced in the GMP Cell Therapy Laboratory.
THE MEDICINE THAT OUR PATIENTS NEED
The Clínica Universidad de Navarra, with headquarters based in Pamplona and Madrid, is a high-resolution hospital that lies at the forefront of personalized medicine in our country.
It is recognised for its teaching and research work, the prestige of its professionals. and its trajectory in the diagnosis and treatment of highly complex pathologies.
Our patients are out focus
Thanks to the full-time dedication of our healthcare professionals, we follow a personalized medical approach that is centred on our patients and their family members.
We generate knowledge
Our hospital is associated with the University of Navarra; thus, in addition to treating patients, our specialists engage in continuous training, research, and teaching activities.
Researching for a cure
Our specialists carry out research to offer new solutions to our patients, as we strive to change the course of diseases with the aid of continuous research.
Always working as a team
Cooperation between specialists of multidisciplinary teams is embedded in or DNA in order to address diseases in a comprehensive way and offer the best options to each patient.
Unique medical technology in Spain
The hospital is furnished with the most advanced equipment for the diagnosis and treatment of all sorts of diseases.
High-resolution medicine
We use the most advanced diagnostic technology and multidisciplinary work with a view to provide a diagnosis within the first 24-48 hours and treatment within the first 72 hours.