Scientific publications
Venoarterial extracorporeal membrane oxygenation with or without simultaneous intra-aortic balloon pump support as a direct bridge to heart transplantation: results from a nationwide Spanish registry
Barge-Caballero G (1,2), Castel-Lavilla MA (3), Almenar-Bonet L (4), Garrido-Bravo IP (2,5), Delgado JF (2,6), Rangel-Sousa D (7), González-Costello J (8), Segovia-Cubero J (2,9), Farrero-Torres M (3), Lambert-Rodríguez JL (10,11), Crespo-Leiro MG (1,2), Hervás-Sotomayor D (12), Portolés-Ocampo A (13), Martínez-Sellés M (2,14), De la Fuente-Galán L (2,15), Rábago-Juan-Aracil G (16), González-Vílchez F (17), Mirabet-Pérez S (18), Muñiz J (2,19), Barge-Caballero E (1,2).
OBJECTIVES:
To investigate the potential clinical benefit of an intra-aortic balloon pump (IABP) in patients supported with venoarterial extracorporeal membrane oxygenation (VA-ECMO) as a bridge to heart transplantation (HT).
METHODS:
We studied 169 patients who were listed for urgent HT under VA-ECMO support at 16 Spanish institutions from 2010 to 2015. The clinical outcomes of patients under simultaneous IABP support (n = 73) were compared to a control group of patients without IABP support (n = 96).
RESULTS:
There were no statistically significant differences between the IABP and control groups with regard to the cumulative rates of transplantation (71.2% vs 81.2%, P = 0.17), death during VA-ECMO support (20.6% vs 14.6%, P = 0.31), transition to a different mechanical circulatory support device (5.5% vs 5.2%, P = 0.94) or weaning from VA-ECMO support due to recovery (2.7% vs 0%, P = 0.10). There was a higher incidence of bleeding events in the IABP group (45.2% vs 25%, P = 0.006; adjusted odds ratio 2.18, 95% confidence interval 1.02-4.67). In-hospital postoperative mortality after HT was 34.6% in the IABP group and 32.5% in the control group (P = 0.80). One-year survival after listing for urgent HT was 53.3% in the IABP group and 52.2% in the control group (log rank P = 0.75). Multivariate adjustment for potential confounders did not change this result (adjusted hazard ratio 0.94, 95% confidence interval 0.56-1.58).
CONCLUSIONS:
In our study, simultaneous IABP therapy in transplant candidates under VA-ECMO support did not significantly reduce morbidity or mortality.
CITATION Interact Cardiovasc Thorac Surg. 2019 Jun 30. pii: ivz155. doi: 10.1093/icvts/ivz155
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