Scientific publications

Transvaginal ultrasound for preoperative assessment of myometrial invasion in patients with endometrial cancer: a systematic review and meta-analysis

Alcázar JL(1), Orozco R(2), Martinez-Astorquiza Corral T(3), Juez L(1), Utrilla-Layna J(1), Mínguez JA(1), Jurado M(1).

(1) Department of Obstetrics and Gynecology, Clínica Universidad de Navarra, School of Medicine, University of Navarra, Pamplona, Spain.
(2) Department of Obstetrics and Gynecology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
(3) Department of Obstetrics and Gynecology, Hospital Universitario Cruces, Bilbao, Spain.

Magazine: Ultrasound in Obstetrics & Ginecology

Date: May 22, 2015

Control del embarazo y parto. Dar a luz. Clínica Universidad de Navarra [SP]

Transvaginal ultrasound (TVS) has been extensively used for assessing myometrial infiltration (MI) in endometrial cancer (EC). However, there is no clear evidence up to date about the overall diagnostic performance.

To perform a systematic review about the diagnostic accuracy of TVS in the preoperative detection of deep MI in patients with EC, comparing subjective and objective methods.

An extensive search was performed in Medline (Pubmed) and EMBASE from January 1989 to December 2014. Eligibility criteria were studies using TVS for preoperative assessment of MI subjective assessment and/or objective measurements, specifically Gordon's (the ratio of the distance between endometrium-myometrium interface and maximum tumor depth to the total myometrial thickness) and Karlsson's (endometrial tumor thickness/anterior-posterior uterine diameter ratio) approaches] in women with EC, using the surgical-pathologic data as a reference standard. Quality was assessed using PRISMA guidelines and QUADAS-2 tool.

Our extended search identified a total of 184 citations but we finally examined the full text of the 24 articles. Overall pooled sensitivity, specificity, positive likelihood ratio (LR+) and negative likelihood ratio (LR-) of TVS for detecting deep myometrial infiltration was 82% (95% CI, 76-87%), 81% (95 % CI, 76-85%), 4.3 (95% CI, 3.6-5.3) and 0.22 (95% CI, 0.16-0.30), respectively. We did not observed differences among all three methods in terms of diagnostic performance. Significant heterogeneity was found for sensitivity and specificity for all three methods (I2 values ranging from 60.57 to 94.96). The main limitation was that very few studies compared different approaches in the same set of patients.

Diagnostic performance of TVS for detecting deep myometrial infiltration in women with endometrial cancer is moderate.

CITATION  Ultrasound Obstet Gynecol. 2015 May 22. doi: 10.1002/uog.14905.

you maybe interested


The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra


The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra


Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra