Scientific publications 

Post-transplant lymphoproliferative disease after liver transplantation

Herrero JI (1), Panizo C (2).

(1) Medicina Interna, Clínica Universidad de Navarra, España.
(2) Instituto de Investigación Sanitaria de Navarra (IdiSNA). Pamplona.

Magazine: Revista Española de Enfermedades Digestivas

Date: Jan 12, 2018

Haematology and Hameotherapy Hepatology

ABSTRACT

We have read the article "Post-transplant lymphoproliferative disease in liver transplant recipients" with great interest.

This article reports a series of liver transplant recipients with post-transplant lymphoproliferative disease (PTLD). The effect on patient survival and the potential benefit of rituximab-based therapy are highlighted. Rituximab is a chimeric antibody against the CD20 surface marker.

This marker is found in most PTLD of a B cell origin. A recent study from our center also highlighted the role of rituximab in PTLD therapy (3). The overall response rate of patients treated with rituximab was 66% in both series.

In our series, this included heart, kidney and liver transplant recipients. Rituximab-based therapy was also associated with an increased overall survival. Rituximab should be considered as part of the first-line therapy in patients with PTLD when CD20 expression is present.

CITATION  Rev Esp Enferm Dig. 2018 Jan 9;110. doi: 10.17235/reed.2017.5387/2017

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