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Phase I/IIa clinical trial to evaluate the feasibility, safety and antitumor activity of autologous car-t slamf7 lymphocytes in multiple myeloma.
THE OBJECTIVE OF THIS TRIAL IS TO EVALUATE THE SAFETY, TOLERABILITY AND EFFECTIVE DOSE OF ITS NEWLY DEVELOPED INVESTIGATIONAL DRUG, THE CHIMERIC T-LYMPHOCYTE RECEPTOR CHIMERIC ANTIGEN RECEPTOR (CAR) DRUG PRODUCT FOR LYMPHOCYTE SIGNALING ACTIVATION MOLECULE F7 (SLAMF7) (HEREAFTER REFERRED TO AS T-CAR SLAMF7). T-CAR SLAMF7 IS IN THE CLINICAL RESEARCH PHASE, WHICH MEANS THAT IT HAS NOT YET RECEIVED APPROVAL FROM THE HEALTH AUTHORITIES AS A DRUG TO TREAT YOUR DISEASE. TO DATE, T-CAR SLAMF7 HAS ONLY BEEN USED IN ANIMAL RESEARCH. THIS CLINICAL TRIAL WILL BE THE FIRST TIME IT WILL BE TESTED IN HUMANS AS AN INVESTIGATIONAL DRUG.
Technical Summary
- PHASE I/IIA CLINICAL TRIAL TO EVALUATE THE FEASIBILITY, SAFETY AND ANTITUMOR ACTIVITY OF AUTOLOGOUS CAR-T SLAMF7 LYMPHOCYTES IN MULTIPLE MYELOMA.
- Code EudraCT: 2019-001264-30
- Protocol number: CARAMBA-1
- Promoter: UNIVERSITAETSKLINIKUM WUERZBURG
* The trials only admit a limited number of patients and are subject to inclusion and exclusion criteria. The specialist who assesses your case will inform you of the conditions required to participate in the clinical trial.
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