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Clinical trial of CLR 131 in patients with selected relapsed or refractory B-lymphocyte malignancies (CLOVER-1) and expansion cohort in patients with Waldenström's macroglobulinemia.

THE PRIMARY OBJECTIVE OF THIS TRIAL IS TO DETERMINE WHETHER CLR 131 IS EFFECTIVE FOR THE TREATMENT OF WALDENSTRÖM'S MACROGLOBULINEMIA (WM). CLR 131 IS AN EXPERIMENTAL RADIOPHARMACEUTICAL. THE TERM "EXPERIMENTAL" MEANS THAT CLR 131 IS NOT APPROVED BY ANY GOVERNMENT AGENCY, SUCH AS THE EUROPEAN MEDICINES AGENCY (EMA), THE HEALTH AUTHORITY THAT APPROVES NEW DRUGS TO BE PRESCRIBED FOR USE IN THE EUROPEAN UNION (EU). THE EMA HAS PERMITTED THE USE OF CLR 131 IN THIS TRIAL.

Status
In recruitment
headquarters
Multisede

Technical Summary

  • PHASE II, OPEN-LABEL, MULTICENTER STUDY OF CLR 131 IN PATIENTS WITH SELECTED RELAPSED OR REFRACTORY (R/R) B-LYMPHOCYTE MALIGNANCIES (CLOVER-1) AND EXTENSION COHORT IN PATIENTS WITH WALDENSTRÖM'S MACROGLOBULINEMIA (CLOVER-WAM) PART B
  • Code EudraCT: 2020-005297-10
  • Protocol number: DCL-16-001
  • Promoter: Cellectar Biosciences, Inc.
  • Link to Clinical Trials

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