Publicações científicas

Sleeve Gastrectomy Reduces Body Weight and Improves Metabolic Profile also in Obesity-Prone Rats

Moncada R (1,2,3), Becerril S (1,2), Rodríguez A [ES] (1,2,4), Méndez-Giménez L (1,2,4), Ramírez B (1,2,4), Catalán V [ES] (1,2,4), Gómez-Ambrosi J [ES] (1,2,4), Gil MJ [ES] (1,2,5), Fernández S (1,2,6), Cienfuegos JA (1,2,7), Valentí V (1,2,7), Frühbeck G (8,9,10,11).
(1) CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain.
(2) Obesity & Adipobiology Group, Instituto de Investigación Sanitario de Navarra (IdiSNA), Pamplona, Spain.
(3) Department of Anesthesia, Clínica Universidad de Navarra, Pamplona, Spain.
(4) Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain.
(5) Department of Biochemistry, Clínica Universidad de Navarra, Pamplona, Spain.
(6) Department of Otorhinolaryngology, Clínica Universidad de Navarra, Pamplona, Spain.
(7) Department of Surgery, Clínica Universidad de Navarra, Pamplona, Spain.
(8) CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain.
(9) Obesity & Adipobiology Group, Instituto de Investigación Sanitario de Navarra (IdiSNA), Pamplona, Spain.
(10) Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain.
(11) Department of Endocrinology & Nutrition, Clínica Universidad de Navarra, Avda. Pío XII, 36, 31008, Pamplona, Spain.

Revisão:Obesity Surgery

Data: 3/Out/2015

Cirurgia Geral e Digestiva Endocrinologia e Nutrição [ES] Área de Obesidade Bioquímica Clínica [ES]

BACKGROUND:

Susceptibility to obesity is associated with a notable inter-individual variation. The aim of the present study was to compare the effectiveness of sleeve gastrectomy (SG) on weight loss and metabolic profile in obesity-prone (OP) rats vs animals that are non-susceptible to obesity (NSO).

METHODS:

Young male Wistar rats (n = 101) were put in a diet-induced obesity (DIO) programme with ad libitum access to a high-fed diet (HFD) during 12 months. Body weight and food intake were regularly registered. Thereafter, rats were ranked by final body weight to identify the obesity-prone (OP) (n = 13) and non-susceptible to obesity (NSO) (n = 14) animals. OP and NSO rats were submitted to surgical interventions (sham operation, SG and pair-fed to the amount of food eaten by sleeve-gastrectomized rats). Body weight, food intake, energy expenditure, body temperature, fat pads weight, and metabolic profiling were analysed 4 weeks after surgical or dietary interventions.

RESULTS:

SG in both OP and NSO rats decreased body weight as compared to sham and pair-fed groups (P < 0.05), mainly due to reductions in subcutaneous and perirenal fat mass (P < 0.001). Total weight loss achieved in sleeve-gastrectomized OP and NSO rats was higher than that of pair-fed ones (P < 0.05), showing that the SG effect goes beyond caloric restriction.

In this regard, sleeve-gastrectomized rats exhibited significantly (P < 0.05) increased basal rectal temperature together with upregulated brown adipose tissue Ucp-1 protein expression levels. A significant (P < 0.05) improvement in insulin sensitivity was also observed in both OP and NSO animals that underwent SG as compared with pair-fed counterparts.

CONCLUSION:

Our findings provide the first evidence that obesity-prone rats also benefit from surgery responding effectively to SG, as evidenced by the significant body weight reduction and the metabolic profile improvement.

CITAÇÃO DO ARTIGO  Obes Surg. 2015 Oct 3.

talvezlhe interesse

QUE TECNOLOGIA UTILIZAMOS? 

A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OS NOSSOS
PROFISSIONAIS

Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.

Imagen profesionales de la Clínica Universidad de Navarra

RAZÕES PARA VIR
À CLÍNICA

Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.

Imagen del edificio de la Clínica Universidad de Navarra