PUBLICAÇÕES científicas

Neoangiogenesis in early cervical cancer: correlation between color Doppler findings and risk factors. A prospective observational study

Jurado M, Galván R, Martinez-Monge R, Mazaira J, Alcazar JL [ES].
Department of Gynecology, Clínica Universitaria de Navarra, School of Medicine, University of Navarra, Pamplona, Spain

Revisão:World Journal of Surgical Oncology

Data: 1/Nov/2008

Oncologia Radioterapêutica Ginecologia e Obstetrícia

Background
The aim of the present article was to evaluate whether angiogenic parameters as assessed by transvaginal color Doppler ultrasound (TVCD) may predict those prognostic factors related to recurrence.

Methods
A total of 27 patients (mean age: 51.3 years, range: 29 to 85) with histologically proven early stage invasive cervical cancer were evaluated by TVCD prior to surgery. Subjective assessment of the amount of vessels within the tumor (scanty-moderate or abundant) and pulsatility index (PI) were recorded. All patients underwent radical hysterectomy and pelvic lymph node dissection. Postoperative treatment (RT or chemoradiotherapy) was given according to risk factors (positive lymph nodes, parametrial and vaginal margin involvement, depth stromal invasion, lymph-vascular space involvement)

Results
Tumors with abundant vascularization were significantly associated with pelvic lymph node metastases, depth stromal invasion > 10 mm, lymph-vascular space involvement, tumor diameter > 17.5 mm, and parametrial involvement. Postoperative treatment was significantly more frequent in patients with abundant vascularization (OR: 20.8, 95% CIs: 2 to 211). The presence of scanty-moderate vascularization with a PI < 0.82 or abundant vascularization with either PI > 0.82 or PI < 0.82 was associated with high-risk group in 94.4% of the cases (OR: 21.2, 95% CI: 1.9 to 236.0)

Conclusions
The results are consistent with a relationship between tumor angiogenesis and prognostic factors for recurrence in early cervical cancer. Abundant vascularization and PI < 0.82 may be related to postoperative treatment due to risk factors.

CITAÇÃO DO ARTIGO  World J Surg Oncol. 2008 Nov 25;6:126

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