Publicações científicas

Comparative study between thiopental and propofol in short-duration anesthesia

Monedero Rodríguez P [ES], Panadero Sánchez A [ES], García Pedrajas F, Carrera Hueso J, Catalá Bauset JC, Arroyo Carreras JL.
Departamento de Anestesiología y Reanimación, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra.

Revisão:Revista Española de Anestesiología y Reanimación

Data: 1/Mai/1991

Anestesia e Cuidados Intensivos [ES]

In a randomized study, 80 healthy unpremedicated female patients were included. For short gynaecological procedures (curettage) they were anaesthetized with either propofol 2 mg/kg (n = 40) or thiopentone 5 mg/kg (n = 40) in combination with nitrous oxide/oxygen (1/1).

Supplementary doses of propofol (25 mg) or thiopentone (50 mg) were given when necessary during the procedure. Propofol caused a significant fall in arterial blood pressure (greater than thiopentone in diastolic pressure) and a decrease in heart rate (thiopentone did not change heart rate).

Discomfort on injection was similar in both groups. Recovery times were shorter in propofol group: Patients opened their eyes at 1.3 minutes, were awake at 2.2 minutes and could seat with no help at 5.2 minutes. In the thiopentone group, there was a greater incidence of nausea.

Propofol was associated with euphoria, "clear-headedness" and pleasant dreams more than thiopentone. We conclude that propofol is a good alternative to thiopentone in short operative procedures.

CITAÇÃO DO ARTIGO Rev Esp Anestesiol Reanim. 1991 May-Jun;38(3):153-5

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