Publicações científicas

Allergenicity and cross-reactivity of pine pollen

G. Gastaminza [ES] (1,2) , M. Lombardero (3) , G. Bernaola (4) , I. Antepara (5) , D. Muñoz (1) , P. M. Gamboa (5) , M. T. Audicana (1), C. Marcos (6) and I. J. Ansotegui (1)
(1) Hospital Santiago Apóstol, Unidad de Alergología, Vitoria, Spain
(2) Department of Allergology and Clinical Immunology, University Clinic, University of Navarra, Pamplona, Spain
(3) ALK-Abelló, Madrid, Spain
(4) Hospital Galdakao, Unidad de Alergología, Galdakao, Spain
(5) Servicio de Alergología, Hospital de Basurto, Bilbao, Spain
(6) Sección de Alergia, Complejo Hospitalario Universitario,Vigo, Spain

Revisão:Clinical and Experimental Allergy

Data: 1/Set/2009

Alergologia e Imunologia Clínica

BACKGROUND
Pine pollen has long been considered a non-allergenic pollen. The large size of the grain and its low levels of proteins are the main reasons invoked to explain this low allergenicity. The aim of this study was to describe the main allergenic bands of Pinus radiata (PR) and its cross-reactivity with other pine species, other conifers and grass pollen.

METHODS
Sixty-five pine-pollen-allergic patients (51% also sensitized to grass pollen) were studied. Skin prick tests (SPT) to a battery of allergens including PR, Pinus pinea, Pinus sylvestris, Pinus nigra and Cupressus sempervirens pollens and specific IgE determination to PR and Pinus strobus were performed. IgE-immunoblotting to a PR extract and other pine pollens was also carried out. UniCAP inhibition and immunoblotting inhibition studies were performed to assess the cross-reactivity between different pollens.

RESULTS
The SPTs were positive with all the pine pollen extracts tested in 69% of the patients. Specific IgE was positive to PR or P. strobus in 77% of the patients, and to Lolium perenne in 51%. Nine different allergenic bands were detected. The two main allergens were a 42 kDa band recognized by 85% of the patients and a band of approximately 6-8 kDa recognized by 40%. A high degree of cross-reactivity was observed between different pine pollen species, but not between pines and C. sempervirens pollen. A partial cross-reactivity could be seen between pine and grass pollens only in patients also sensitized to L. perenne.

CONCLUSIONS
Pine pollen should be considered as a potential allergenic pollen especially where this pollen is abundant. The detection of a high number of patients that were monosensitized to pine pollen suggests the possibility of treating these patients with specific immunotherapy.

CITAÇÃO DO ARTIGO  Clin Exp Allergy. 2009 Sep;39(9):1438-46

talvezlhe interesse

QUE TECNOLOGIA UTILIZAMOS? 

A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OS NOSSOS
PROFISSIONAIS

Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.

Imagen profesionales de la Clínica Universidad de Navarra

RAZÕES PARA VIR
À CLÍNICA

Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.

Imagen del edificio de la Clínica Universidad de Navarra