PUBLICAÇÕES científicas

Patterns of response after preoperative treatment in gastric cancer

Díaz-González JA, Rodríguez J [ES], Hernández-Lizoain JL, Ciérvide R, Gaztañaga M, San Miguel I, Arbea L [ES], Aristu JJ [ES], Chopitea A [ES], Martínez-Regueira F, Valentí V, García-Foncillas J, Martínez-Monge R, Sola JJ.
Division of Radiation Oncology, Clínica Universidad de Navarra, Pamplona, Spain

Revisão:International Journal of Radiation Oncology,Biology, Physics

Data: 1/Jul/2011

Oncologia Médica Cirurgia Geral e Digestiva Oncologia Radioterapêutica Anatomia Patológica [ES] Área de Tumores do Tubo Digestivo

PURPOSE
To analyze the rate of pathologic response in patients with locally advanced gastric cancer treated with preoperative chemotherapy with and without chemoradiation at our institution.

METHODS AND MATERIALS
From 2000 to 2007 patients were retrospectively identified who received preoperative treatment for gastric cancer (cT3-4/ N+) with induction chemotherapy (Ch) or with Ch followed by concurrent chemoradiotherapy (45 Gy in 5 weeks) (ChRT). Surgery was planned 4-6 weeks after the completion of neoadjuvant treatment. Pathologic assessment was used to investigate the patterns of pathologic response after neoadjuvant treatment.

RESULTS
Sixty-one patients were analyzed. Of 61 patients, 58 (95%) underwent surgery. The R0 resection rate was 87%. Pathologic complete response was achieved in 12% of the patients. A major pathologic response (<10% of residual tumor) was observed in 53% of patients, and T downstaging was observed in 75%. Median follow-up was 38.7 months. Median disease-free survival (DFS) was 36.5 months. The only patient-, tumor-, and treatment-related factor associated with pathologic response was the use of preoperative ChRT. Patients achieving major pathologic response had a 3-year actuarial DFS rate of 63%.

CONCLUSIONS
The patterns of pathologic response after preoperative ChRT suggest encouraging intervals of DFS. Such a strategy may be of interest to be explored in gastric cancer.

CITAÇÃO DO ARTIGO  Int J Radiat Oncol Biol Phys. 2011 Jul 1;80(3):698-704

talvezlhe interesse

QUE TECNOLOGIA UTILIZAMOS? 

A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OS NOSSOS
PROFISSIONAIS

Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.

Imagen profesionales de la Clínica Universidad de Navarra

RAZÕES PARA VIR
À CLÍNICA

Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.

Imagen del edificio de la Clínica Universidad de Navarra