PUBLICAÇÕES científicas

Intensive chemotherapy in the treatment of patients with metastatic breast cancer

Salgado J.E., Aramendía J.M. [ES], Fernández-Hidalgo O.A., Lozano E., Rebollo J., Martínez-Monge R., Subirá M.L., Brugarolas A.
Departamento de Oncología, Facultad de Medicina, Universidad de Navarra

Revisão:Revista de Medicina de la Universidad de Navarra

Data: 1/Jul/1997

Oncologia Radioterapêutica Área do Cancro da Mama Oncologia Médica

PURPOSE
Phase II study with intensive chemotherapy and autologous stem cells support in patients with metastatic breast cancer.

METHODS
Forty-nine patients were treated with high-doses of two cytotoxic drugs and support with stem cells obtained from several leukapheresis without movilitation. The cells were reinfused forty-eight hours after finishing the administration of chemotherapy.

RESULTS
Twenty-one patients (47%, CI-95%: 32.4-63.3%) achieved a complete remission. The objective responses rate was 73% (CI-95%: 57.2-85%). Overall and progression-free survival up to 4 years were 31% and 20%, respectively. Ten patients remain progression-free among 17 and 46 months. The most frequent extramedullary toxicity was hepatic and renal. Three patients (6%) died during the procedure.

CONCLUSIONS
Intensive chemotherapy with hematopoietic support yields, with a moderate toxicity, a high objective response and complete remission rate. A small group of patients achieves a long progression-free survival.

CITAÇÃO DO ARTIGO Rev Med Univ Navarra. 1997 Jul-Sep;41(3):143-51

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