Scientific publications

Utility of immunophenotypic and immunogenotypic analysis in the study of necrotic lymph nodes

Mar 1, 1999 | Magazine: Virchows Archive

Vega F, Lozano MD, Alcalde J, Pardo-Mindan FJ.
Department of Pathology, Clínica Universitaria de Navarra, Pamplona, Spain.


We report a case of complete lymph node necrosis.

No specific aetiology could be determined by morphology, but a B lymphoid population and clonal rearrangement of the immunoglobulin heavy chain gene were demonstrated in immunophenotypic and immunogenotypic studies performed using DNA extracted from paraffin embedded necrotic tissue. In the setting of lymph node necrosis, we suggest that immunohistochemical and gene rearrangement studies may provide additional diagnostic information.

CITATION  Virchows Arch. 1999 Mar;434(3):245-8