Scientific publications

Role of amino acid PET in HGGs: limitations and perspectives

Verger A (1,2), Arbizu J (3), Law I (4).

(1) Department of Nuclear Medicine & Nancyclotep Imaging Platform, CHRU Nancy, Lorraine University, Nancy, France - a.verger@chru-nancy.fr.
(2) IADI, INSERM, Lorraine University, Nancy, France - a.verger@chru-nancy.fr.
(3) Department of Nuclear, Clinica Universidad de Navarra, University of Navarra, Pamplona, Spain.
(4) Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Magazine: The Quarterly Journal of Nuclear Medicine and Molecular Imaging

Date: Apr 26, 2018

Nuclear Medicine [SP]

ABSTRACT

Positron emission tomography (PET) using radiolabelled amino acids was recently recommended by the Response Assessment in Neuro-Oncology (RANO) working group as an additional tool in the diagnostic assessment of brain tumours.

The aim of this review is to summarise available literature data on the role of amino-acid PET imaging in high-grade gliomas (HGGs), with regard to diagnosis, treatment planning and follow-up of these tumours. Indeed, amino acid PET applications are multiple throughout the evolution of HGGs.

However, certain limitations such as lack of specificity, uncertain value for grading and prognostication or the limited data for treatment monitoring should to be taken into account, the latter of which are further developed in this review.

Notwithstanding these limitations, amino acid PET is becoming increasingly accessible in many nuclear medicine centres. Larger prospective cohort prospective studies are thus needed in order to increase the clinical value of this modality and enable its extended use to the largest number of patients.

CITATION  Q J Nucl Med Mol Imaging. 2018 Apr 26. doi: 10.23736/S1824-4785.18.03092-3

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