Prolonged idiotypic vaccination against follicular lymphoma
Susana Inoges (a,b), Ascension Lopez-Diaz de Cerio (a), Natalia Zabalegui (a), Elena Soria(a), Helena Villanueva(a), Carlos Panizo (c), Arancha Rodriguez-Caballero (d), Lilia Suarez (d), Fernando Pastor (a), Mercedes Rodriguez-Calvillo (a), Alberto Orfao (d), Maurizio Bendandi (a,b,c),
(a) Laboratory of Immunotherapy, Oncology Division, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
(b) Immunotherapy Program, Cell Therapy Area, University of Navarra, Pamplona, Spain
(c) Department of Hematology, University of Navarra Hospital, University of Navarra, Pamplona, Spain
(d) General Flow Cytometry Service, Center for Cancer Investigation, University of Salamanca, Salamanca, Spain
Magazine: Leukemia and Lymphoma
Date: Jan 1, 2009Hematología y Hemoterapia [SP] Cell Therapy Area [SP]
During the last 2 decades, idiotypic vaccination has provided proof of principle of biological efficacy, clinical efficacy and clinical benefit in small follicular lymphoma trials.
However, with the exception of anecdotal reports, most patients have received no more than 10 doses of their customised idiotype (Id) vaccine. Therefore, it is not known whether prolonged usage of idiotypic vaccination is safe. Since 2002, 18 previously treated patients with follicular lymphoma have received extended idiotypic vaccination at our institution outside clinical trials. Vaccination was provided as a compassionate alternative to no further treatment, and was meant to be stopped only upon complete consumption of the available patient- and tumor-specific vaccine [Id-keyhole limpet hemocyanin + granulocyte-macrophage colony-stimulating factor (Id-KLH + GM-CSF)], or in case of disease relapse or any serious non-local toxicity. So far, 18 patients have received an average of 18 doses of Id vaccine (median: 17; mean: 18; range: 10-31). Eleven patients are still actively receiving idiotypic vaccination: some of them are now over more than 6 years.
Toxicity has been systematically negligible and mostly local. No patient has abandoned the vaccination program because of toxicity. Prolonged idiotypic vaccination with the soluble protein Id-KLH + GM-CSF formulation is safe and well tolerated.
CITATION Leuk Lymphoma. 2009 Jan;50(1):47-53
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