Prevalence and distribution of hepatitis C virus genotypes in Spain during the 2000-2015 period (The GEHEP 005 study)
Aguilera A (1), Navarro D (1), Rodríguez Frias F (2), Viciana I (3), Martínez-Sapiña AM (4), Rodríguez MJ (5), Martró E (6), Del Carmen Lozano M (7), Coletta E (8), Cardeñoso L 9, Suárez A (10), Trigo M (11), Rodríguez-Granjer J (12), Montiel N (13), de la Iglesia A (14), Alados JC (15), Vegas C (16), Bernal S (17), Fernández-Cuenca F (18), Pena MJ (19), Reina G (20), García-Bujalance S (21), Echevarria MJ (22), Benítez L (23), Pérez-Castro S (24), Ocete D (25), García-Arata I (26), Guerrero C (27), Rodríguez-Iglesias M (28), Casas P (29), García F (29).
(1) Complexo Hospitalario Universitario de Santiago de Compostela.
(2) Hospital Universitari Vall d'Hebron, Barcelona.
(3) Hospital Clínico Universitario Virgen de la Victoria, Malaga.
(4) Hospital Universitario Miguel Servet, Zaragoza.
(5) Hospital Universitario Ramón y Cajal, Madrid.
(6) Hospital Universitari Germans Trías i Pujol, Badalona; CIBER en Epidemiología y Salud Pública.
(7) Hospital Universitario Virgen del Rocio, Sevilla.
(8) Hospital Clínico Universitario Valladolid.
(9) Hospital Universitario de la Princesa, Madrid.
(10) Hospital Clínico San Carlos, Madrid.
(11) Complexo Hospitalario de Pontevedra.
(12) Hospital Universitario Virgen de las Nieves, Granada.
(13) Hospital Costa del Sol, Marbella.
(14) Complejo Hospitalario Universitario de Huelva.
(15) Hospital del SAS de Jerez de la Frontera.
(16) Fundación Jiménez Díaz, Madrid.
(17) Hospital Universitario Virgen de Valme, Sevilla.
(18) Hospital Universitario Virgen Macarena, Sevilla.
(19) Hospital Doctor Negrín, Las Palmas de Gran Canaria.
(20) Clínica Universitaria de Navarra, Pamplona.
(21) Hospital Universitario La Paz, Madrid.
(22) Hospital Universitario Donostia, San Sebastían.
(23) Hospital Universitario Puerta de Hierro, Majadahonda.
(24) Hospital Álvaro Cunqueiro, Vigo.
(25) Consorcio Hospital General Universitario de Valencia.
(26) Hospital Universitario de Fuenlabrada.
(27) Hospital General Universitario Morales Meseguer, Murcia.
(28) Hospital Universitario Puerta del Mar, Cádiz.
(29) Complejo Hospitalario Universitario Granada, Centro San Cecilio-PTS, Instituto de Investigación Ibs-Granada.
Magazine: Journal of Viral Hepatitis
Date: Mar 1, 2017Clinical Microbiology [SP]
We report the largest study on the prevalence and distribution of HCV genotypes in Spain (2000-2015), and we relate them with clinical, epidemiological and virological factors.
Patients from 29 hospitals in 10 autonomous communities (Andalusia, Aragon, Castilla-Leon, Catalonia, Galicia, Canary Islands, Madrid-Community, Valencian-Community, Murcia Region and Basque Country) have been studied. Annual distribution of HCV genotypes and subtypes, as well as gender, age, transmission route, HIV and/or HBV-coinfection, and treatment details were recorded.
We recruited 48595 chronically infected HCV patients; median age 51 years (IQR, 44-58), 67.9% male, 19.1% HIV-coinfected, 23.5% HBV-coinfected. Parenteral transmission route was the most frequent (58.7%). Genotype distribution was: 66.9% GT1 (24.9% subtype1a and 37.9% subtype1b), 2.8% GT2, 17.3% GT3, 11.4% GT4, and 0.1% GT5 and 0.02% GT6.LiPA was the most widely HCV genotyping test used (52.4%).
HCV subtype 1a and genotypes 3 and 4 were closely associated with male gender, parenteral route of infection, and HIV and HBV coinfection; in contrast, subtype 1b and genotype 2 were associated with female gender, non-parenteral route and mono-infection. Age was related to genotype distribution, and different patterns of distribution and biodiversity index were observed between different geographical areas. Finally, we describe how treatment and changes in transmission routes may have affected HCV genotype prevalence and distribution patterns.
We present the most recent data on molecular epidemiology of hepatitis C virus in Spain. This study confirms that genotype distributions vary with age, sex, HIV and HBV-coinfection and within geographical areas and epidemiological groups.
CITATION J Viral Hepat. 2017 Mar 1. doi: 10.1111/jvh.12700
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