Scientific publications

Pediatric meningosarcoma: clinical evolution and genetic instability.

May 1, 2005 | Magazine: Pediatric Neurology

de Mesa RL, Sierrasesúmaga L, de Cerain AL, Calasanz MJ, Patiño-García A.

This report presents a female diagnosed with a frontoparietal interhemispheric meningosarcoma who, parallel to the clinical worsening, revealed an increase in the genetic instability (in bleomycin cultures) and the complexity of the karyotypes, with the acquisition of a clonal deletion of 17p13 (the locus for the TP53 tumor suppressor gene).

The genetic findings of this patient suggest that the increased genetic instability could contribute to tumor progression as well as to treatment resistance, possibly in the background of the clonal deletion of TP53.

CITATION  Pediatr Neurol. 2005 May;32(5):352-4