Scientific publications
Mohs micrographic surgery in dermatofibrosarcoma protuberans: Rate and risk factors for recurrence in a prospective cohort study from the Spanish Registry of Mohs Surgery (REGESMOHS) and review of the literature
Lula María Nieto-Benito 1 , Cristina Ciudad-Blanco 1 2 , Onofre Sanmartin-Jimenez 3 , Joan R Garces 4 5 , Manuel A Rodríguez-Prieto 6 , Eva Vilarrasa 4 5 , Esther de Eusebio-Murillo 7 , Román Miñano-Medrano 8 , Begoña Escutia-Muñoz 9 , Beatriz Gonzalez-Sixto 10 , Juan L Artola-Igarza 11 , Alberto Alfaro Rubio 12 , Pedro Redondo 13 , Yolanda Delgado-Jiménez 14 15 , Julia M Sánchez-Schmidt 16 , Irati Allende-Markixana 17 , María L Alonso-Pacheco 18 , Beatriz García-Bracamonte 19 , Pablo de la Cueva Dobao 20 , Raquel Navarro-Tejedor 15 , Ricardo Suarez-Fernández 1 , Lucia Carnero-González 21 , Hugo Vázquez-Veiga 22 , Lucia Barchino-Ortiz 2 , Verónica Ruiz-Salas 4 , Pedro Sánchez-Sambucety 6 , José L López-Estebaranz 8 , Rafael Botella-Estrada 9 , Carlos Feal-Cortizas 10 , Antonio Martorell Calatayud 12 , Pilar Gil 13 , Victoriano Morales-Gordillo 14 , Agustí Toll-Abelló 16 , Izascun Ocerin-Guerra 17 , Matías Mayor-Arenal 18 , Carmen Garcia-Donoso 19 , Natividad Cano-Martinez 2 20 , Laura Sainz-Gaspar 22 , Miguel A Descalzo 23 , Ignacio Garcia-Doval 23 , REGESMOHS (Registro Español de Cirugía de Mohs)
Abstract
Characterization of patients, surgery procedures and the risk factors for dermatofibrosarcoma protuberans (DFSP) recurrences is poorly defined.
In this study, we aimed to describe the demographics, tumor characteristics and interventions of DFSP treated with Mohs micrographic surgery (MSS) to determine the rate and risk factors for recurrence.
Data were collected from REGESMOHS, a nationwide prospective cohort study of patients treated with MMS in Spain. From July 2013 to February 2020, 163 patients with DFSP who underwent MMS were included. DFSP was mostly located on trunk and extremities.
Recurrent tumors had deeper tumor invasion and required higher number of MMS stages. Paraffin MMS was the most frequently used technique. Overall recurrence rate was 0.97 cases/100 person-years (95% IC = 0.36-2.57). No differences were found in epidemiological, tumor, surgery characteristics or surgical technique (frozen or paraffin MMS [p = 0.6641]) in terms of recurrence.
Median follow-up time was 28.6 months with 414 patient-years of follow-up. In conclusion, we found an overall low recurrence rate of DFSP treated with MMS. None of the studied risk factors, including MMS techniques, was associated with higher risk for recurrence.
CITATION Exp Dermatol. 2021 May;30(5):717-722. doi: 10.1111/exd.14291. Epub 2021 Feb 13
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