Looking into the "Garden of the Hesperides": new drugs for hepatocellular carcinoma
Castañón Alvarez E (1), Giallombardo M, Gil-Bazo I, Papadimitriou K, Pauwels P, Peeters M, Rolfo C.
(1) Department of Oncology, Clínica Universidad de Navarra Pamplona, Spain
Advanced hepatocellular carcinoma remains an entity that is hard to approach therapeutically and has shown disappointing results in terms of survival. For many years, the only accepted option for this setting was the use of a multikinase inhibitor, sorafenib. Nevertheless, through the years, a deeper knowledge has arisen about how pathogenic pathways correlate with hepatocellular carcinoma. In this review, we provide an update of the most recent data regarding new agents under investigation and new possible targets for future treatments.
CITATION Minerva Chir. 2015 Apr;70(2):119-29. Epub 2015 Jan 23