Is stress cardiovascular magnetic resonance really useful to detect ischemia and predict events in patients with different cardiovascular risk profile?
Esteban-Fernández A (1), Coma-Canella I (2), Bastarrika G (3), Barba-Cosials J (2), Azcárate-Agüero PM (4).
(1) Departamento de Cardiología, Clínica Universidad de Navarra, Pamplona, España.
(2) Departamento de Cardiología, Clínica Universidad de Navarra, Pamplona, España.
(3) Departamento de Radiología, Clínica Universidad de Navarra, Pamplona, España.
(4) Servicio de Cardiología, Hospital San Pedro, Logroño, España.
The aim of this study was to evaluate the diagnostic and prognostic usefulness of stress cardiovascular magnetic resonance (stress CMR) in patients with different cardiovascular risk profile and to assess if the degree of hypoperfusion is important to guide clinical decisions.
We included patients submitted to adenosine stress CMR to rule out myocardial ischemia. We evaluated its diagnostic accuracy with likelihood ratio (LR) and its prognostic value with survival curves and a Cox regression model.
295 patients were studied. The positive LR was 3.40 and the negative one 0.47. The maximal usefulness of the test was found in patients without previous ischemic cardiomyopathy (positive LR 4.85), patients with atypical chest pain (positive LR 8.56), patients with low or intermediate cardiovascular risk (positive LR 3.87) and those with moderate or severe hypoperfusion (positive LR 8.63). Sixty cardiovascular major events were registered.
The best survival prognosis was found in patients with a negative result (p=0.001) or mild hypoperfusion (p=0.038). In the multivariate analysis, a moderate or severe hypoperfusion increased cardiovascular event probability (HR=2.2; IC 95% 1.26-3.92), with no differences between a mild positive and a negative result (HR=0.93; IC 95% 0.38-2.28).
Stress CMR was specially useful in patients with low or intermediate cardiovascular risk, patients with atypical chest pain, patients without previous ischemic cardiomyopathy and those with moderate or severe hypoperfusion. Hypoperfusion degree was the main issue factor to guide clinical decisions.
CITATION Arch Cardiol Mex. 2016 Jul 30. pii: S1405-9940(16)30072-6. doi: 10.1016/j.acmx.2016.07.002