Involvement of cardiomyocyte survival-apoptosis balance in hypertensive cardiac remodeling
Fortuño M.A., López N., González A., Díez J.
Division of Cardiovascular Pathophysiology, School of Medicine, University of Navarra, Pamplona, Spain
Magazine: Expert Review of Cardiovascular Therapy
Date: Jul 1, 2003Cardiology
The balance between cell death and cell survival is a tightly controlled process, especially in terminally differentiated cells, such as the cardiomyocyte. Accumulating data support a role for cardiomyocyte apoptosis in the development of several cardiac diseases, including the transition from hypertensive compensatory hypertrophy to heart failure.
This review briefly summarizes the status of the knowledge regarding the death-survival balance of cardiomyocytes in the context of hypertensive heart disease. Several molecular and cellular aspects as well as the most relevant pathophysiological implications are presented.
Moreover, diagnosis tools under development and the possibilities for pharmacological intervention are also examined.
CITA DEL ARTÍCULO Expert Rev Cardiovasc Ther. 2003 Jul;1(2):293-307
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