Scientific publications
Intratumoral STING Agonist Injection Combined with Irreversible Electroporation Delays Tumor Growth in a Model of Hepatocarcinoma
Aritz Lasarte-Cia 1 , Teresa Lozano 1 , David Cano 2 , Celia Martín-Otal 1 , Flor Navarro 1 , Marta Gorraiz 1 , Noelia Casares 1 , Isabel Vivas 2 , Juan José Lasarte 1
Background/aim: Irreversible electroporation (IRE) showed promising results for small-size tumors and very early cancers. However, further development is needed to evolve this procedure into a more efficient ablation technique for long-term control of tumor growth. In this work, we show that it is possible to increase the antitumor efficiency of IRE by simmultaneously injecting c-di-GMP, a STING agonist, intratumorally.
Materials and methods: Intratumoral administration of c-di-GMP simultaneously to IRE was evaluated in murine models of melanona (B16.OVA) and hepatocellular carcinoma (PM299L).
Results: The combined therapy increased the number of tumor-infiltrating IFN-γ/TNF-α-producing CD4 and CD8 T cells and delayed tumor growth, as compared to the effect observed in groups treated with c-di-GMP or IRE alone.
Conclusion: These results can lead to the development of a new therapeutic strategy for the treatment of cancer patients refractory to other therapies.
CITATION Biomed Res Int. 2021 Jan 27;2021:8852233. doi: 10.1155/2021/8852233. eCollection 2021
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