Incidental findings in negative sentinel lymph nodes of patients with malignant melanoma: report of three cases
Martinez-Peñuela, Ana MD (1); Olmo, Julio Del MD (2); Boán, José Francisco MD (3); Idoate, Miguel Angel MD (1)
(1) Department of Pathology; (2) Department of Dermatology; and (3) Nuclear Medicine Department; Clínica Universitaria de Navarra, Pamplona, Spain.
We present three cases of benign SLN that were clinically suspicious for involvement by metastatic melanoma and where found to be involved with other diseases or deposits previously unknown, A 44-year-old woman presented with a 1.6 cm pigmented lesion on her back.
An excisional skin biopsy revealed a 1.7-mm-thick superficial spreading melanoma. The patient had bilateral silicone breast prostheses. An axillary sentinel lymph node (SLN) excision was performed. The lymph node examination showed a granulomatous reaction, with numerous macrophages.
There was no evidence of metastatic melanoma by immunohistochemical studies with S-100, Melan-A, and HMB-45.
CITATION Am J Dermatopathol. 2007 Feb;29(1):104-5